Product Name :
MMG-11
Description:
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 µM for Pam3CSK4-induced hTLR2/1 and 5.7 µM for Pam2CSK4-induced hTLR2/6 responses.
CAS:
313254-94-3
Molecular Weight:
306.27
Formula:
C15H14O7
Chemical Name:
ethyl 5-[2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl]furan-2-carboxylate
Smiles :
CCOC(=O)C1=CC=C(CC(=O)C2=CC=C(O)C(O)=C2O)O1
InChiKey:
IIDUJWIVMGALOG-UHFFFAOYSA-N
InChi :
InChI=1S/C15H14O7/c1-2-21-15(20)12-6-3-8(22-12)7-11(17)9-4-5-10(16)14(19)13(9)18/h3-6,16,18-19H,2,7H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Moxifloxacin} MedChemExpress|{Moxifloxacin} Anti-infection|{Moxifloxacin} Purity & Documentation|{Moxifloxacin} Data Sheet|{Moxifloxacin} supplier|{Moxifloxacin} Autophagy}
Additional information:
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity.{{Spermidine} web|{Spermidine} Endogenous Metabolite|{Spermidine} Biological Activity|{Spermidine} Description|{Spermidine} supplier|{Spermidine} Epigenetic Reader Domain} MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.PMID:33295191 7 µM for Pam3CSK4-induced hTLR2/1 and 5.7 µM for Pam2CSK4-induced hTLR2/6 responses.|Product information|CAS Number: 313254-94-3|Molecular Weight: 306.27|Formula: C15H14O7|Chemical Name: ethyl 5-[2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl]furan-2-carboxylate|Smiles: CCOC(=O)C1=CC=C(CC(=O)C2=CC=C(O)C(O)=C2O)O1|InChiKey: IIDUJWIVMGALOG-UHFFFAOYSA-N|InChi: InChI=1S/C15H14O7/c1-2-21-15(20)12-6-3-8(22-12)7-11(17)9-4-5-10(16)14(19)13(9)18/h3-6,16,18-19H,2,7H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MMG-11 neither shows cellular toxicity nor interference with signaling induced by other TLR agonists, IL-1β or TNF. MMG-11 (0.01-100 µM) shows no cytotoxic effects up to 100 µM in peripheral blood mononuclear cells (PBMCs).|Products are for research use only. Not for human use.|