June 2016

Consistent with the tissue-particular Msh2 deletion revealed in Figure 1B, Msh2D/D and Msh2D/2 mice did not present any alteration in instability in liver or cortex, though instability in these tissues (large in liver and reasonable in cortex) was removed in Msh22/2 mice

We first decided the expression ranges of Msh2 protein in striatal extracts from mice with Msh2+/+, Msh2+/2, Msh2D/D, Msh2D/two and Msh22/2 genotypes. Msh2 protein amounts ended up minimized by ,60%…