Product Name :
TCS 2002
Description:
TCS 2002 is a potent inhibitor of GSK-3β with IC50 value of 35 nM . Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase and functions by phosphorylating a serine or threonine residue on its target protein. GSK3β plays an important role in neuronal cell development, energy metabolism and body pattern formation. TCS 2002 is a potent GSK -3β inhibitor with IC50 value of 35 nM. (S) -TCS 2002 and (R) -TCS 2002 inhibited GSK-3β with IC50 values of 34 and 140 nM, respectively. TCS 2002 exhibited good bioavailability (F=40%) and solubility (38 μg/mL). (S) -TCS 2002 showed no inhibitory activity against 12 tyrosine kinases and 10 serine/threonine kinases up to 10 μM, indicating that (S) -TCS 2002 was a highly selective GSK -3β inhibitor . In mice, cold water stress (CWS) induced tau hyperphosphorylation at several GSK -3β directed sites such as S199, Thr205, Thr231 and Ser396. (S) -TCS 2002 significantly inhibited tau phosphorylation by 35% .
CAS:
1005201-24-0
Molecular Weight:
338.38
Formula:
C18H14N2O3S
Chemical Name:
2-[3-(4-methanesulfinylphenyl)-1-benzofuran-5-yl]-5-methyl-1,3,4-oxadiazole
Smiles :
CC1=NN=C(O1)C1C=C2C(=CC=1)OC=C2C1C=CC(=CC=1)S(C)=O
InChiKey:
RCKYSTKYIVULEK-UHFFFAOYSA-N
InChi :
InChI=1S/C18H14N2O3S/c1-11-19-20-18(23-11)13-5-8-17-15(9-13)16(10-22-17)12-3-6-14(7-4-12)24(2)21/h3-10H,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Etokimab} site|{Etokimab} Interleukin Related|{Etokimab} Protocol|{Etokimab} Formula|{Etokimab} supplier|{Etokimab} Cancer}
Additional information:
TCS 2002 is a potent inhibitor of GSK-3β with IC50 value of 35 nM .{{D-Glucose} MedChemExpress|{D-Glucose} Metabolic Enzyme/Protease|{D-Glucose} Protocol|{D-Glucose} Description|{D-Glucose} manufacturer|{D-Glucose} Epigenetics} Glycogen synthase kinase 3 (GSK-3) is a serine/threonine protein kinase and functions by phosphorylating a serine or threonine residue on its target protein.PMID:23927631 GSK3β plays an important role in neuronal cell development, energy metabolism and body pattern formation. TCS 2002 is a potent GSK -3β inhibitor with IC50 value of 35 nM. (S) -TCS 2002 and (R) -TCS 2002 inhibited GSK-3β with IC50 values of 34 and 140 nM, respectively. TCS 2002 exhibited good bioavailability (F=40%) and solubility (38 μg/mL). (S) -TCS 2002 showed no inhibitory activity against 12 tyrosine kinases and 10 serine/threonine kinases up to 10 μM, indicating that (S) -TCS 2002 was a highly selective GSK -3β inhibitor . In mice, cold water stress (CWS) induced tau hyperphosphorylation at several GSK -3β directed sites such as S199, Thr205, Thr231 and Ser396. (S) -TCS 2002 significantly inhibited tau phosphorylation by 35% .|Product information|CAS Number: 1005201-24-0|Molecular Weight: 338.38|Formula: C18H14N2O3S|Chemical Name: 2-[3-(4-methanesulfinylphenyl)-1-benzofuran-5-yl]-5-methyl-1,3,4-oxadiazole|Smiles: CC1=NN=C(O1)C1C=C2C(=CC=1)OC=C2C1C=CC(=CC=1)S(C)=O|InChiKey: RCKYSTKYIVULEK-UHFFFAOYSA-N|InChi: InChI=1S/C18H14N2O3S/c1-11-19-20-18(23-11)13-5-8-17-15(9-13)16(10-22-17)12-3-6-14(7-4-12)24(2)21/h3-10H,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|