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Hemangioma, probably the most common tumor of infancy, is usually a benign vascular neoplasm resulting in the abnormal proliferation of endothelial cells, with an estimated prevalence of five to ten [1]. These tumors are characterized by a fast development phase through the initial year of life, followed by slow involution, which could continue till the age of 10sirtuininhibitor2 years. Despite the progress that has been accomplished inside the clinical observation and treatment of hemangioma, its etiology remains elusive [2].www.impactjournals/oncotargetTo investigate the etiology of this illness, we and others reported a transgenic model of hemangioma that expresses the polyoma middle T antigen (PyMT), the principal oncoprotein on the murine polyomavirus. The transgenic mice were characterized by spontaneous hemangiomas [3, 4]. Nonetheless, there are actually nonetheless some unresolved challenges within this model that limit its application. Initially, constitutive PyMT overexpression may cause embryonic lethality, resulting in a low frequency of transgenic founders and failure to create offspring. Second, it is actually difficult to distinguish involving direct andOncotargetindirect effects from the PyMT protein on endothelial cells du.