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Zhang et al. Parasites Vectors (2015)8:37 DOI 10.1186/s13071-015-0650-RESEARCHOpen AccessAn association of Aquaporin-4 with all the immunoregulation of liver pathology in mice infected with Schistosoma japonicumWeiwei Zhang1, Jifeng Zhu1, Xian Song1, Zhipeng Xu1, Xue Xue2, Xiaojun Chen1, Xiaowei Yang1, Yong Li1, Xiaoxiao Dong1, Sha Zhou1, Wei Li1, Yingying Qian3, Feng Liu1 and Chuan Su1AbstractBackground: Schistosomiasis is a chronic parasitic illness that affects around 200 million individuals. In Schistosomiasis japonica and mansoni, parasite eggs had been trapped in host liver and stimulated the CD4+T cell responses to regulate the formation with the granulomas. Subsequently, excessive granulomatous response in some heavily, and/or repeatedly infected men and women could lead to chronic liver fibrosis and circulatory impairment. Therefore, elucidation from the mechanisms of these responses will not only offer extra information and facts to better recognize the mechanisms of the immunoregulation in schistosomiasis, but in addition help to design new therapies to control granuloma-associated immunopathology. The role of aquaporin-4 (AQP4) in water transport has been extensively investigated within the central nervous system (CNS). Not too long ago, studies have shown that AQP4 expresses in immune method and lack of AQP4 in mice results in substantially less CD4+CD25+ T regulatory cells (Treg cells) under physiological condition, certainly one of the subpopulations of CD4+T cells which restrains immunopathology in hosts with schistoso.