Ailability of H2-antagonists in stomach had a greater clinical significance in remedy of peptic ulcer (Pellinger et al., 2010). Ranitidine hydrochloride is really a histamine H2-receptor antagonist. It was widely prescribed in active duodenal ulcers, gastric ulcers, Zollinger-Ellison syndrome, gastroesophageal reflux illness, and erosive esophagitis. The encouraged adult oral dosage of ranitidine was 150 mg twice each day or 300 mg once every day. The efficient remedy of erosive esophagitis required administration of 150 mg of ranitidine 4 instances each day. A conventional dose of 150 mg can inhibit gastric acid secretion as much as five hours but not as much as ten hours. An option dose of 300 mg cause plasma fluctuations; hence a sustained release dosage type of ranitidine was desirable (Betlach et al., 1991). In addition, due to the brief biological half-life of drug ( 2.53 hours), and consequently, a frequent dosing regimen wasOpen Access dx.doi.org/10.4062/biomolther.2013.This can be an Open Access report distributed beneath the terms on the VEGF165 Protein Species Creative Commons Attribution Non-Commercial License (creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, supplied the original work is adequately cited.Copyright ?2014 The Korean Society of Applied Pharmacologyneeded. Many approaches happen to be used in designing oral ranitidine sustained types with higher absorption and lasting drug effects. One example is, floating drug delivery made of hydroxypropyl methylcellulose (Dave et al., 2004), carbopol (Adhikary and Vavia, 2008) ethyl cellulose (Mastiholimath et al., 2008), sodium alginate (Rohith et al., 2009) and osmotic technologies (Kumar et al., 2008) can enhance the drug retain within the stomach and resulting in elevated absorption. On the other hand, because of high viscosity floating drug delivery possess the disadvantage of becoming tough to develop. Oral in situ gel, or atmosphere sensitive gel, is a new dosage type which has been applied in drug delivery not too long ago. Compared with classic formulations, in situ gels have been administered as low viscosity options, and below the sensitive atmosphere, the polymer changed conformation creating a gel, so it cannot only prolong the contact time in between the drug as well as the absorptive web pages in the stomach, but also release drug slowly and constantly, therefore, it was especially useful for all those drugs utilized chronically. Among oral in situ gel, the phase transition could be induced by a shift in temperature as for the thermo gelling xyloglucan (Miyazaki et al., 2001) or byReceived Dec 20, 2013 Revised Jan 26, 2014 Accepted Jan 27,Corresponding AuthorE-mail: rjdrma@163 Tel: +86 21 64370045, Fax: +86 21biomolther.orgBiomol Ther 22(2), 161-165 (2014)the presence of NFKB1, Human (His) cations as for gellan gum (Miyazaki et al., 2001), sodium alginate, pectin (Kubo et al., 2004). Gellan gum is definitely an anionic deacetylated, exocellular polysaccharide secreted by Pseudomonas elodea with a tetrasaccharide repeating unit of 1b-L-rhamnose, 1b-D-glucuronic, acid and 2b-D-glucose. The mechanism of gelation involves the formation of double-helical junction zones followed by aggregation of the double-helical segments to form a 3-D network by complexation with cations and hydrogen bonding with water (Grasdalen and Smidsroed, 1987; Chanrasekaran et al.,1988; Chanrasekaran and Thailambal, 1990). A lot of paper previously examined the feasibility of working with gellan formulations for the oral sustained delivery of drug (Miyaza.