Nd [54]. Additionally, 5-azaC also can inhibit RNA methylation, E.K., R.T. and T.A.R.; validation, regulatory layer for chondrogenic differentiation [55]. Consequently, it’s affordable to an additional R.Z. and T.A.R.; formal analysis, J.V., E.K., L.D. and T.A.R.; investigation, J.V., K.K., K.K. and T.A.R.; sources, R.Z., T.A.R. and C.M.; writing–original draft preparation, J.V., E.K., C.M., R.Z., contemplate that solution when the effect of 5-azaC treatment is evaluated.Cells 2021, 10,18 ofSupplementary Materials: The following are offered on the net at https://www.mdpi.com/article/10 .3390/cells10102678/s1, Table S1: Sequences of primer pairs made use of for the PCR array analyses, Table S2: Sequences of primer pairs utilised for the RT-qPCR reactions, Table S3: Sequences of primer pairs applied for the qMSP analyses, Table S4: Sequence information of the 3 UTR regions of Dnmt3a, Ogt and Tet1 genes with insert flanking T7 promoters for antisense probe preparation, Figure S1: Photomicrograph of an E15 mouse embryo utilized for in situ hybridization as a negative manage (no distinct RNA probe was utilised), Figure S2: Quantitative (relative optical density) values in the Dnmt3a-, Tet1- and Ogt-specific in situ hybridization photomicrographs. Author Contributions: Conceptualization, R.Z. and T.A.R.; methodology, J.V., E.K., R.T. and T.A.R.; validation, R.Z. and T.A.R.; formal evaluation, J.V., E.K., L.D. and T.A.R.; investigation, J.V., E.K., K.K. and T.A.R.; resources, R.Z., T.A.R. and C.M.; writing–original draft preparation, J.V., E.K., C.M., R.Z., T.A.R.; writing–review and editing, J.V., R.Z., T.A.R., C.M.; visualization, J.V., E.K. and T.A.R.; supervision, R.Z., T.A.R.; project administration, R.Z.; funding acquisition, R.Z., C.M., T.A.R. All authors have read and agreed for the published version of the manuscript. Funding: This function was supported by the 2020/R/20/2502 Gedeon Richter Plc. grant awarded to J.V. The publication was supported by the EFOP-3.6.1-16-2016-00022 plus the EFOP-3.6.3-VEKOP-16-201700009 projects, the projects are co-financed by the European Union along with the European Social Fund. C.M. was supported by the Premium Postdoctoral Analysis Fellowship from the E v Lor d Study Network (ELKH), along with the Young PF-05105679 Autophagy Researcher Excellence Programme (grant number: FK-134304) on the National Research, Improvement and Innovation Workplace, Hungary. Project no. TKP2020-NKA04 has been implemented using the help provided from the National Study, Development and Innovation Fund of Hungary, financed below the 2020-4.1.1-TKP2020 funding scheme. T.A.R. received funding from the National Study, Improvement and Innovation Fund, Hungary (grant number: K131588). Institutional Overview Board Histone Methyltransferase| Statement: The study was conducted based on the recommendations in the Declaration of Helsinki, and authorized by the Animal Care and Protection Committee at the University of Debrecen (2/2018/DEM ). Informed Consent Statement: Not applicable. Data Availability Statement: The information presented within this study are accessible on request from the corresponding author. Acknowledgments: The authors would prefer to thank Krisztina B in the Division of Anatomy, Histology and Embryology for their skillful and superb technical assistance. Conflicts of Interest: The authors declare that they have no competing interests. This paper was written by the authors within the scope of their academic and study positions. None of your authors have any relationships that could be construed as biased or inappropriate. The f.