Siglec-2/CD22 Antibody (OX-97) Summary
Made to Mouse CD22
NB100-63595 recognises domain 2 of the murine cell surface glycoprotein CD22, which is a member of the sialoadhesin family. CD22 is expressed on a subpopulation of mature B-lymphocytes and may modulate signalling through the B-cell antigen receptor.
IgG1
Monoclonal
Rat
CD22
Protein G purified
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Applications/Dilutions
- Flow Cytometry 1:50-1:100
Reactivity Notes
Reacts with Mouse.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS (pH 7.4)
0.09% Sodium Azide
1 mg/ml
Protein G purified
Alternate Names for Siglec-2/CD22 Antibody (OX-97)
- B-cell receptor CD22
- BL-CAM
- B-lymphocyte cell adhesion molecule
- CD22 antigenMGC130020
- CD22 molecule
- CD22
- sialic acid binding Ig-like lectin 2
- Sialic acid-binding Ig-like lectin 2
- Siglec2
- Siglec-2
- SIGLEC2FLJ22814
- T-cell surface antigen Leu-14
Background
CD22 is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140kD. It is expressed in both the cytoplasm and cell membrane of B lymphocytes. CD22 antigen appears early in B cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Unlike other B cell markers, CD22 membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias. CD22 is also strongly expressed in hairy cell leukemia. There are two different isoforms of CD22. It exists predominantly as a monomer of the beta isoform but can also be found as a heterodimer composed of the beta isoform and a second, shorter isoform (CD22 alpha).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.