Properdin Antibody (10-24) Summary

Native purified factor P from human serum

NB100-64677 recognizes human complement factor P, a 53 kDa glycosylated protein present in blood serum. Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections. NB100-64677 does not inhibit function of complement factor P.

IgG1

Monoclonal

Mouse

CFP

Protein A purified

Test in a species/application not listed above to receive a full credit towards a future purchase.

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Borate buffered saline

0.09% Sodium Azide

1.0 mg/ml

Protein A purified