MMP-7 Antibody Summary
Synthetic peptide from human matrilysin (PUMP-1)
Cytoplasmic.
This reacts with the 28 kDa protein (pro form) and 18 kDa (active form) of MMP 7.
IgG
Polyclonal
Rabbit
MMP7
IgG purified
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Applications/Dilutions
- Immunohistochemistry
- Immunohistochemistry-Paraffin 1:25 – 1:50
Immunohistochemistry-Paraffin: use at 30mins at RT using ABC method. Suitable for formalin fixed paraffin embedded sections. No special pretreatment is required. Depending upon the fixation conditions and the staining system employed, optimal incubation conditions should be determined by the end user.
Reactivity Notes
Cross-reacts with Human. Not yet tested in other species.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS
Sodium Azide
IgG purified
Alternate Names for MMP-7 Antibody
- EC 3.4.24
- EC 3.4.24.23
- Matrilysin
- matrin
- matrix metallopeptidase 7 (matrilysin, uterine)
- matrix metalloproteinase 7 (matrilysin, uterine)
- Matrix metalloproteinase-7
- MMP7
- MMP-7
- MPSL1
- Pump-1 protease
- PUMP1
- PUMP-1
- uterine matrilysin
- Uterine metalloproteinase
Background
Matrix Metalloproteinases (MMPs) belong to a family of proteases that are essential for the breakdown of extracellular matrix (ECM). They are thus important in apoptosis, tumor cell growth, invasion, and metastasis, as well as angiogenesis and wound healing. Most MMPs contain common domain structures that include a signal sequence, a propeptide, a catalytic domain, and a hemopexin-like (Hpx) domain. MMP7, also known as Matrilysin, is responsible for hydrolyzing proteoglycans and ECM glycoproteins. It is expressed in normal cells, specifically glandular epithelial cells.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.