MAdCAM-1 Antibody (CA 102.2C1) Summary
Bacterially expressed human MAdCAM-1
Membrane; single pass type I membrane protein.
NB100-63277 recognizes human MAdCAM-1 (mucosal addressin cell adhesion molecule -1), a 40kD protein expressed by vascular endothelium. Clone CA102.2C1 has been reported to block the binding of human cells expressing alpha4 Beta7 to immobilized MAdCAM-1 in vitro.
IgG1
Monoclonal
Mouse
MADCAM1
Protein A purified
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
Applications/Dilutions
- Western Blot 1:100-1:2000
- ELISA 1:100-1:2000
- Functional
Reactivity Notes
Reacts with Human.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
No Preservative
1.0 mg/ml
Protein A purified
Alternate Names for MAdCAM-1 Antibody (CA 102.2C1)
- hMAdCAM-1
- MACAM1
- MAdCAM1
- MAdCAM-1
- mucosal addressin cell adhesion molecule 1
- mucosal addressin cell adhesion molecule-1
- mucosal vascular addressin cell adhesion molecule 1
Background
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM1 (alpha4 beta7), L selectin, and VLA4 (alpha4 beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full length nature of some variants has not been determined.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.