GITR/TNFRSF18 Antibody (AP-MAB0860) Summary
mouse CD25+CD4+ T cells
This was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse CD25+CD4+ T cells.
IgG2
Monoclonal
Rat
TNFRSF18
Protein A or G purified
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Applications/Dilutions
- Flow Cytometry 1:10-1:1000
- CyTOF-ready
Flow Cytometry and Blocking mouse GITR (in vitro and in vivo). Extremely low level of LPS (< 0.002EU/ug IgG)
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
A 0.2 um filtered solution in PBS – Azide free
No Preservative
1.0 mg/ml
Protein A or G purified
Alternate Names for GITR/TNFRSF18 Antibody (AP-MAB0860)
- Activation-inducible TNFR family receptor
- AITR
- AITRTNF receptor superfamily activation-inducible protein
- CD357 antigen
- CD357
- GITR
- GITR-D
- GITRtumor necrosis factor receptor superfamily member 18
- Glucocorticoid-induced TNFR-related protein
- TNFRSF18
- tumor necrosis factor receptor superfamily, member 18
Background
GITR, glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18, and AITR (in humans). It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Treg cells. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-kB activation, and abrogate the inhibitory function of CD25+CD4+ T reg cells. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.