Caspase-6 Antibody (6CSP01 (7.1.65)) Summary
Recombinant human Caspase 6 prodomain.
Caspase 6 prodomain.
Cytoplasmic.
Caspase 6 (6CSP01 (7.1.65))
IgG1 Kappa
Monoclonal
Mouse
CASP6
Protein A or G purified
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Applications/Dilutions
- Immunoprecipitation 2ug/mg
Immunoprecipitation (denatured verified, with protein G): use at a concentration of 2ug/mg of lysate. Not tested in any other applications. Optimal dilutions/concentrations should be determined by the end user.
Reactivity Notes
Cross-reacts with Human. Not yet tested in other species.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
10mM PBS (pH 7.4) and 0.2% BSA
0.09% Sodium Azide
Protein A or G purified
Alternate Names for Caspase-6 Antibody (6CSP01 (7.1.65))
- Apoptotic protease Mch-2
- CASP6
- CASP-6
- caspase 6, apoptosis-related cysteine peptidase
- caspase 6, apoptosis-related cysteine protease
- Caspase6
- Caspase-6
- EC 3.4.22
- Mch2
- MCH2EC 3.4.22.59
Background
Caspases play a major role in the transduction of the apoptotic signal and execution of apoptosis in mammalian cells. Caspase 3 (CPP32) and Caspase 6 (Mch2) are the major active caspases in apoptotic cells, and are activated in response to distinct apoptosis inducing stimuli and in all cell lines analyzed. Both CPP32 and Mch2 are present in apoptotic cells as multiple active species. Caspase 6 cleaves nuclear mitotic apparatus protein (NuMA) and mediates the shrinkage and fragmentation of nuclei.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.