CD11b Antibody (AP-MAB0813) Summary
Mouse CD11a+ T Cells
Microglia Marker, Macrophage Marker
The was selected for its ability to detect mouse CD11b+ T cells by FC.
IgG2b
Monoclonal
Rat
ITGAM
Protein A or G purified
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Applications/Dilutions
- Blocking/Neutralizing 50-200 molar excess
Blocking of CD11b mediated cell-cell adhesion. Endotoxin Level: Extremely low level of LPS (< 0.002EU/ug IgG).
127 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Reactivity Notes
Mouse.
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
A 0.2 um filtered solution in PBS – Azide free
No Preservative
1.0 mg/ml
Protein A or G purified
Alternate Names for CD11b Antibody (AP-MAB0813)
- antigen CD11b (p170)
- CD11 antigen-like family member B
- CD11b antigen
- CD11b
- CD11Bintegrin, alpha M (complement component receptor 3, alpha; also known as CD11b(p170), macrophage antigen alpha polypeptide)
- Cell surface glycoprotein MAC-1 subunit alpha
- CR-3 alpha chain
- CR3AMGC117044
- Integrin alpha M
- integrin alpha-M
- integrin, alpha M (complement component 3 receptor 3 subunit)
- ITGAM
- Leukocyte adhesion receptor MO1
- MAC-1
- MAC1A
- macrophage antigen alpha polypeptide
- MO1A
- neutrophil adherence receptor alpha-M subunit
- Neutrophil adherence receptor
- SLEB6
Background
CD11b is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement coated particles. It is identical to CR3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. CD11b is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. The Mac1 CD11b antigen is present on macrophages, granulocytes, natural killer cells, blood monocytes. CD11b is expressed on 8% spleen cells, 44% bone marrow cells and less than 1% of thymocytes and is commonly used as a microglial marker in nervous tissue.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.