In silico homology lookups throughout many motif databases revealed a few Ubiquitin Binding Domains at the N-terminus of mutant USP25mD153-E679X (in which the 1st 153 amino acids have been deleted, and the protein is truncated at amino acid 679) could also oligomerize (Determine 3C)
It is assumed that the presence of UBDs in DUBs favor the precise recognition of the ubiquitin modifications, whilst the N- and Cterminal extended extensions flanking the DUB-conserved catalytic core…