Neutrophil Elastase/ELA2 Antibody (4B11) Summary
ELA2 (NP_001963 168 a.a. – 267 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. VLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
ELA2 (4B11)
IgG2a Kappa
Monoclonal
Mouse
ELANE
IgG purified
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Applications/Dilutions
- ELISA
Antibody reactivity against recombinant protein on ELISA. GST alone used as a negative control.
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS (pH 7.4)
No Preservative
IgG purified
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Neutrophil Elastase/ELA2 Antibody (4B11)
- Bone marrow serine protease
- EC 3.4.21
- EC 3.4.21.37
- ELA2
- ELA2granulocyte-derived elastase
- ELANE
- elastase 2, neutrophil
- elastase, neutrophil expressed
- Elastase-2
- GE
- HLEelastase-2
- HNE
- Human leukocyte elastase
- Leukocyte Elastase
- Medullasin
- NE
- Neutrophil Elastase
- PMN elastase
- PMN-E
- polymorphonuclear elastase
- SCN1
Background
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Elastase 2 hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the proteins release from activated neutrophils. Elastase 2 may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
product targets : MAPK_Compound_Library inhibitors