Product Name :
Rabbit anti-PDE6B Polyclonal Antibody
Synonym :
CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; rd1; RP40
Host :
Rabbit
Species Reactivity:
Human, Mouse, Rat
Specificity :
Predicted Reactivity:
Applications :
WB 1:500 – 1:2000IHC 1:50 – 1:100IF 1:50 – 1:100
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PDE6B (NP_001138763.1).
Concentration :
Purification :
Affinity purification
Clonality:
Polyclonal Antibody
Storage Temp.:
Store at -20 ℃Avoid freeze / that cycles
Research areas :
Background :
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt :
P35913
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Synonym CSNB3; CSNBAD2; GMP-PDEbeta; PDEB; rd1; RP40 |Host Rabbit |Species Reactivity Human, Mouse, Rat |Applications WB 1:500 – 1:2000IHC 1:50 – 1:100IF 1:50 – 1:100 |Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human PDE6B (NP_001138763.1). |Positive control Mouse liver,Mouse pancreas,Mouse heart,Rat liver |Properties |Purification Affinity purification |Clonality Polyclonal Antibody |Isotype IgG |Storage Temp. Store at -20 ℃Avoid freeze / that cycles |Storage Buffer Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |Target |Background Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene. |Cellular localization Lipid-anchor,Membrane |UniProt P35913 |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-PDE6B Polyclonal Antibody
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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