Integrin alpha 2b/CD41 Antibody (CLB-48) Summary
The antibody reacts with human trombocytes and megakaryocytes.
IgG1
Monoclonal
Mouse
ITGA2B
Ion exchange chromatography
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Applications/Dilutions
- Immunocytochemistry/Immunofluorescence 1:10-1:2000
The monoclonal antibody is a useful marker for megakaryoblasts and megakaryoblastic leukemias.The antibody can be used for indirect immunofluorescence staining with analysis by cytofluorometry or fluorescence microscopy.
Reactivity Notes
Human
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
20mM Tris (pH 8.0), 0.15M NaCl, 10 mg BSA and 0.001% Merthiolate
No Preservative
Ion exchange chromatography
Alternate Names for Integrin alpha 2b/CD41 Antibody (CLB-48)
- CD41 antigen
- CD41
- CD41BHPA3
- GP2B
- GP2Bintegrin alpha-IIb
- GPalpha IIb
- GPIIb
- GTA
- HPA3
- Integrin alpha 2b
- integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41)
- integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigenCD41B)
- ITGA2b
- ITGAB
- platelet fibrinogen receptor, alpha subunit
- Platelet membrane glycoprotein IIb
- platelet-specific antigen BAK
Background
Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
product targets : PTEN inhibitors