IL-17 RA/IL-17 R Antibody (RM0104-10B27) Summary
Mouse recombinant protein of the extracellular domain of IL-17R
This was produced from a hybridoma (mouse myeloma) fused with spleen cells from a rat immunized with mouse recombinant protein of the extracellular domain of IL-17R.
IgG2b
Monoclonal
Rat
IL17RA
Protein G purified
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Applications/Dilutions
- Western Blot 1:500-1:1000
This antibody detects mouse IL-17R in Western blotting, but not IL-17B R.
Reactivity Notes
Mouse.
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
A 0.2 um filtered solution in PBS
No Preservative
LYOPH
Protein G purified
Reconstitute with 0.2 ml sterilized PBS to a final concentration of 0.5 mg/ml.
Alternate Names for IL-17 RA/IL-17 R Antibody (RM0104-10B27)
- CD217 antigen
- CD217
- Cdw217
- CDw217interleukin 17 receptor
- hIL-17R
- IL-17 R
- IL-17 RA
- IL-17 receptor A
- IL17RA
- IL-17RA
- IL-17RAMGC10262
- IL17Rinterleukin-17 receptor A
- interleukin 17 receptor A
Background
Recently, a number of cytokines belonging to the interleukin IL17 family have been identified. These are termed as IL17B, IL17C and IL17E. IL17 is a potent proinflammatory cytokine that plays roles in a number of diseases including rheumatoid arthritis, multiple sclerosis, and promotion of tumor growth. IL17B, C, and E like IL17 are able to induce proinflammatory responses. However, they do not bind to the IL17 receptor suggesting that additional IL17R related receptor might exist. Receptor for IL17B and IL17E have been independently isolated and have been designated as EV127 (in mouse) and IL17RH1 (in human), respectively. IL17E induces activation of NFkB pathway and like IL17 also induces production of IL8. IL17RH1 mRNA is highly expressed in Kidney and liver and at moderate level in small intestine, colon, and brain.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.