**Background** Homologous recombination (HR) is a high-fidelity DNA repair mechanism essential for maintaining genomic stability, particularly in the repair of double-strand breaks. A critical step in this process is the…
**Background** Phosphodiesterase 2A (PDE2A) is a dual substrate enzyme that metabolizes both cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), although it typically exhibits a higher affinity for cGMP.…
**Background** T-cell activation is a tightly regulated process essential for the adaptive immune response. Among the key regulators, lymphoid tyrosine phosphatase (LYP) plays a critical role in maintaining immune homeostasis…
**Background** Skeletal muscle trauma and inflammation often lead to significant pain and discomfort, which can severely impair physical mobility and quality of life. The management of these conditions typically involves…
**Background** Dipeptidyl peptidase-4 (DPP-4) is a serine protease that plays a critical role in the degradation of incretin hormones, such as glucagon-like peptide-1 (GLP-1), which are essential for glucose homeostasis.…
The mechanical integrity of microscale structures fabricated via embedded 3D printing is fundamentally determined by the interplay between interfacial forces and the yield behavior of soft materials. In this study,…
Metal-organic frameworks (MOFs) with hierarchical pore structures offer significant advantages in applications requiring efficient mass transfer and access to large molecules. This study presents a controlled strategy for constructing such…
The successful identification of selective non-nucleoside inhibitors of DNMT3A from the Medicines for Malaria Venture (MMV) Pathogen Box exemplifies the power of repurposing existing chemical libraries in epigenetic drug discovery.…
The realization of scalable neuromorphic computing hinges on the development of artificial synapses that combine high performance, exceptional reliability, and energy efficiency. While conventional oxide memristors have demonstrated promise in…
The fluorescent probe LXY was synthesized through a straightforward two-step procedure starting from N-(rhodamine 6G) lactam-ethylenediamine (A) and hippuric acid (B). In the first step, compound A (460 mg, 1…