Name :
TRIB2 Protein
Description :
Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate the activation of some intracellular signalling pathways with roles extending from mitosis and cell activation to apoptosis and modulation of gene expression. Tribbles control the timing of mitosis in the prospective mesoderm, allowing cell-shape changes to be completed. This mechanism for coordinating cell division and cell-shape changes may have helped Drosophila to evolve its mode of rapid early development. Trib2 was identified as a downregulated transcript in leukemic cells undergoing growth arrest. Trib2-transduced bone marrow cells exhibited a growth advantage and readily established factor-dependent cell lines. Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML).
Species :
Human
Uniprotkb :
Baculovirus-Insect Cells
Tag :
His,GST
Synonyms :
TRIBBLE, tribbles pseudokinase 2, TRIB2, C5FW, FLJ57420, GS3955, TRB2
Construction :
A DNA sequence encoding the human TRIB2 (NP_067675.1) (Met 1-Asn 343) was fused with the GST tag at the N-terminus and a polyhistidine tag at the C-terminus.
Protein Purity :
> 90 % as determined by SDS-PAGE
Molecular Weight :
Approxiamtely 66 kDa
Endotoxin :
Formulatione :
Supplied as sterile 50mM Tris, 100mM NaCl, 1mM GSH, 0. 5mM PMSF, pH 8.0. Pleasecon tact usfor any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Reconstitution :
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Stability & Storage :
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Shipping :
Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background :
Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate the activation of some intracellular signalling pathways with roles extending from mitosis and cell activation to apoptosis and modulation of gene expression. Tribbles control the timing of mitosis in the prospective mesoderm, allowing cell-shape changes to be completed. This mechanism for coordinating cell division and cell-shape changes may have helped Drosophila to evolve its mode of rapid early development. Trib2 was identified as a downregulated transcript in leukemic cells undergoing growth arrest. Trib2-transduced bone marrow cells exhibited a growth advantage and readily established factor-dependent cell lines. Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML).
References and Literature :
1. Seher, TC. et al., 2000, Curr Biol. 10 (11): 623-9. 2. Keeshan, K. et al., 2006, Cancer Cell. 10 (5): 401-11. 3. Hegedus, Z. et al., 2007, Cell Signal. 19 (2):238-50. 4. Keeshan, K. et al., 2008, Blood Cells Mol Dis. 40 (1): 119-21. 5. Cvetkovic, LV. et al., 2010, J Clin Invest. 120 (3): 713-9.
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