u-Plasminogen Activator/Urokinase Antibody Summary
Native human uPA.
Recognizes human uPA alone and also as a complex under reducing and native conditions.
IgG
Polyclonal
Sheep
PLAU
Protein G purified
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Applications/Dilutions
- Western Blot 1-5 ug/ml
- ELISA 1:100000
Reactivity Notes
Cross reacts with Human.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
50mM Sodium Phosphate (pH 6.6), 0.1M NaCl and 1mM EDTA
No Preservative
1.0 mg/ml
Protein G purified
Alternate Names for u-Plasminogen Activator/Urokinase Antibody
- ATF
- EC 3.4.21
- EC 3.4.21.73
- plasminogen activator, urokinase
- PLAU
- uPA
- u-PA
- uPlasminogen Activator
- u-Plasminogen Activator
- urinary
- Urokinase
- urokinase-type plasminogen activator
Background
Urokinase is a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in the Urokinase gene may be associated with late onset Alzheimer disease and also with decreased affinity for fibrin binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg Val bond in plasminogen. The proprotein is cleaved at a Lys Ile bond by plasmin to form a two chain derivative in which a single disulfide bond connects the amino terminal A chain to the catalytically active, carboxy terminal B chain. This two chain derivative is also called HMW uPA (high molecular weight uPA). HMW uPA can be further processed into LMW uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino terminal fragment. LMW uPA is proteolytically active but does not bind to the uPA receptor.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.