beta Amyloid Antibody (BAM-10) Summary
A synthetic beta-amyloid peptide (1-40) conjugated to KLH.
Cytoplasmic
This antibody reacts with beta-amyloid protein. It stains Amyloid plaques within the cortex and Amyloid deposits in blood vessels. Beta-amyloid deposits are also detected in Lewy body dementia, Downs syndrome, amyloidosis, and in Gram-Parkinson dementia complex. The presence of a large number of neuritic plaques (senile) and neurofibrillary tangles in the cerebral cortex is used as pathological markers for disease state and presents the major criterion for diagnosis of Alzheimers disease at autopsy.
IgG1
Monoclonal
Mouse
APP
Unpurified
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Applications/Dilutions
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin 1:50-1:100
Reactivity Notes
Human.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
Ascites
Sodium Azide
Unpurified
Alternate Names for beta Amyloid Antibody (BAM-10)
- Abeta
- Amyloid beta
- beta-Amyloid Peptide
Background
The cerebral and vascular plaques associated with Alzheimers disease (AD) are mainly composed of amyloid beta peptides (Ab). Ab is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Ab [1-40], Ab [1-42], and Ab [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma secretase during the last APP processing step. Ab [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. Ab antibodies and peptides have been developed as tools for elucidating the biology of AD.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.