XCR1/CCXCR1 Antibody (1097A) [Alexa Fluor® 350] Summary
Met1-Thr31, Ser89-Lys103, His168-His190, Phe251-Tyr267
Accession # P46094
Applications/Dilutions
- Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
Notes
Alternate Names for XCR1/CCXCR1 Antibody (1097A) [Alexa Fluor® 350]
- CCXCR1
- CCXCR1XC chemokine receptor 1
- chemokine (C motif) receptor 1
- chemokine XC receptor 1
- G protein-coupled receptor 5
- GPR5
- GPR5chemokine (C motif) XC receptor 1
- G-protein coupled receptor 5
- Lymphotactin receptor
- XCR1
Background
XCR1, also known as GPR5 and Lymphotactin/SCM-1 (Single Cysteine Motif 1) Receptor, is a 38 kDa member of the G-protein coupled receptor 1 family. It binds XCL1/Lymphotactin/SCM-1 alpha and XCL2/SCM-1 beta. In addition, Human Herpes Virus 8 (HHV8) encodes two viral chemokines vCCL2/vMIP-II and vCCL3/vMIP-III that function as an antagonist and a highly selective agonist, respectively, for XCR1. XCR1 is expressed on neutrophils, CD8+ T cells, NK cells, CD4+ T cells and B cells. Human XCR1 is a 333 amino acid (aa), 7-transmembrane molecule. It contains a 32 aa N-terminus that lacks glycosylation sites and a 42 aa C-terminal cytoplasmic tail. Over the extracellular regions used for immunization, human XCR1 shares 62%, 54% and 64% aa identity with canine, mouse and porcine XCR1, respectively.