UVRAG Antibody (953035) [Alexa Fluor® 750] Summary
Human UVRAG synthetic peptide corresponding to sequences between amino acids 260-360
Accession # Q9P2Y5
Accession # Q9P2Y5
Detects human UVRAG in direct ELISAs.
IgG1
Monoclonal
Mouse
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Applications/Dilutions
- Intracellular Staining by Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
Store the unopened product at 2 – 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for UVRAG Antibody (953035) [Alexa Fluor® 750]
- beclin 1 binding protein
- DHTX
- disrupted in heterotaxy
- p63
- UV radiation resistance associated gene
- UV radiation resistance-associated gene protein
- UVRAG
- VPS38
Background
UV radiation resistance-associated gene protein, or UVRAG, is a multi-function protein of 699 amino acids involved in the regulation of cellular pathways implicated in membrane trafficking. UVRAG activates the Beclin-1-PI3KC3 complex, a critical element in the autophagy signaling pathway. Binding studies show that UVRAG and Beclin-1 directly interact via their coiled-coil domains and that Beclin-1 functions as a platform for the formation of the Bcl-2-UVRAG-PI3KC3 complex. Chromosomal aberrations involving the UVRAG gene are associated with left-right axis malformation, and mutations in the gene have been associated with colon cancer.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.