Thyroglobulin Antibody Summary
Thyroglobulin isolated from human thyroids.
Cytoplasmic
This reacts with human thyroglobulin containing cells in thyroid.
IgG
Polyclonal
Rabbit
TG
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin Neat
Reactivity Notes
Human
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
No buffer
Sodium Azide
Immunogen affinity purified
Alternate Names for Thyroglobulin Antibody
- AITD3
- AITD3TGN
- cog
- TDH3
- Tg
- TGN
- Thyroglobulin
Background
Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimotos thyroiditis, Graves diseases), with the highest level observed in Hashimotos thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.