TIMP-1 Antibody Summary
A synthetic peptide from the N terminal half of human TIMP1.
Cytoplasmic
TIMP1
IgG
Polyclonal
Rabbit
TIMP1
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Frozen 1:100
- Immunohistochemistry-Paraffin 1:10-1:500
This antibody can be used in Immunohistochemistry-paraffin. Staining of formalin fixed tissues requires boiling tissue sections in 10mM Citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Recommended Starting Dilutions*: IHC-FFPE: 1/100 Not tested in other applications. *Optimal dilutions should be determined by the end user.
Reactivity Notes
Not yet tested in other species.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
10mM PBS (pH 7.4) and BSA
Sodium Azide
0.2 mg/ml
Immunogen affinity purified
Alternate Names for TIMP-1 Antibody
- CLGI
- Collagenase inhibitor
- collagenase inhibitor)
- EPATIMP-1
- EPO
- erythroid potentiating activity
- Erythroid-potentiating activity
- Fibroblast collagenase inhibitor
- FLJ90373
- HCI
- metalloproteinase inhibitor 1
- TIMP metallopeptidase inhibitor 1
- TIMP1
- TIMP-1
- TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity
- Tissue inhibitor of metalloproteinases 1
Background
Tissue inhibitor of metalloproteinases-1 (TIMP-1) and Tissue inhibitor of metalloproteinases-2 (TIMP-2) have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-1 forms a complex of 1:1 stoichiometry with activated interstitial collagenases, activated stromelysin, active form of 72kDa Type IV collagenase (also known as MMP-2 or gelatinase A), and latent and active forms 92kDa Type IV collagenase (also known as MMP-0 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
product targets : BMX Kinase inhibitors