TCR gamma/delta Antibody (UC7-13D5) [FITC] Summary
Mouse T cell clone G8
gamma delta T-cell receptor (TCR) complex
IgG
Monoclonal
Armenian Hamster
TRG
Protein A or G purified
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Applications/Dilutions
- Flow Cytometry <= 1 ug/10^6 cells
- Immunoprecipitation 1:10-1:500
- In vitro assay
Reactivity Notes
Mouse.
Packaging, Storage & Formulations
Store at 4C in the dark.
PBS
0.05% Sodium Azide
Protein A or G purified
Notes
Protect conjugated forms from light.
Alternate Names for TCR gamma/delta Antibody (UC7-13D5) [FITC]
- CD3d
- delta polypeptide
- T cell receptor gamma locus
- T3D
- T-cell antigen receptor, gamma polypeptide
- T-cell rearranging gene, gamma
- T-cell receptor, gamma cluster
- TCR gamma/delta
- TCRG
- TiT3
- TRG
Background
The TCR gamma delta heterodimer of the CD3/T-cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. (1) It is expressed during thymopoiesis and on the small subpopulation of gamma delta TCR expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are gamma delta+and have limited receptor diversity. (1, 2) The TCR gamma delta heterodimer recognizes peptide antigen bound to MHC antigens, and subsequent signal transduction mediated by the invariant chains leads to T cell activation. (3) The monoclonal antibody UC7-13D5 is specific for the gamma delta heterodimer and plate-bound UC7-13D5 activates gamma delta TCR-bearing cells. (4-7) This antibody does not react with alpha beta TCR-expressing T cells.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.