Sphingosine Kinase 1/SPHK1 Antibody Summary
Synthetic 15 amino acid peptide from N-terminus of human SPHK1.
N-terminal domain of human
This is specific to the human Sphingosine Kinase Type 1 protein.
Primate (100%). Backed by our 100% Guarantee.
IgG
Polyclonal
Rabbit
SPHK1
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry-Paraffin 20 ug/ml
Reactivity Notes
Reacts with Human.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.1% Sodium Azide
1.0 mg/ml
Immunogen affinity purified
Alternate Names for Sphingosine Kinase 1/SPHK1 Antibody
- EC 2.7.1.91
- SK1
- sphingosine kinase 1
- SPHK1
- SPHKSK 1
- SPK 1
- SPK
- SPK1
Background
Sphingosine kinase (SPHK) phosphorylates sphingosine to form a bioactive lipid mediate, sphingosine 1-phosphate (S1P or SPP). S1P is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival while extracellularly it is a ligand for EDG 1. Expression of SPHK1 and subsequent production of S1P promotes the G1-S transition, protects cells from apoptosis, stimulates migration and angiogenesis and induces tumor formation in mice.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.