Serpin A6/Cortisol Binding Globulin Antibody Summary
Synthetic peptide C-DLFTNQANFSRIT from an internal region of human SERPINA6 / CBG (NP_001747.2).
Human SERPINA6 / CBG.
Primate (92%), Monkey (92%). Backed by our 100% Guarantee.
IgG
Polyclonal
Goat
SERPINA6
Immunogen affinity purified
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Applications/Dilutions
- ELISA 1:100 – 1:2000
- Immunohistochemistry-Paraffin 3-6 ug/ml
IHC: NBP1-52396 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity.
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Orangutan (100%), Gibbon (100%), Marmoset (92%), Bat (85%), Rabbit (85%).
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
TBS (pH 7.3) and 0.5% BSA
0.02% Sodium Azide
0.5 mg/ml
Immunogen affinity purified
Alternate Names for Serpin A6/Cortisol Binding Globulin Antibody
- antitrypsin), member 6
- CBG
- CBGcorticosteroid-binding globulin
- corticosteroid binding globulin
- member 6
- serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
- Serpin A6
- serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)
- transcortin
Background
Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.