SerpinB2 Antibody (930109) [Alexa Fluor® 647] Summary
E. coli-derived recombinant human Serpin B2
Glu2-Ala65, Ala99-Pro415
Accession # P05120
Glu2-Ala65, Ala99-Pro415
Accession # P05120
Detects human Serpin B2 in direct ELISAs.
IgG2b
Monoclonal
Mouse
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Applications/Dilutions
- Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
Store the unopened product at 2 – 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for SerpinB2 Antibody (930109) [Alexa Fluor® 647]
- HsT1201
- Monocyte Arg-serpin
- PAI
- PAI2
- PAI2Urokinase inhibitor
- Placental plasminogen activator inhibitor
- PLANH2
- PLANH2PAI-2
- plasminogen activator inhibitor 2
- plasminogen activator inhibitor, type II (arginine-serpin)
- serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
- Serpin B2
- serpin peptidase inhibitor, clade B (ovalbumin), member 2
- Urokinase Inhibitor
Background
Serpin B2, also known as Plasminogen Activator Inhibitor 2 (PAI-2), is a 415 amino acid serine-type endopeptidase inhibitor with high expression in blood, vasculature and placenta. Its expression is upregulated in pregnancy and in activated monocytes/macrophages by a wide range of viral, bacterial and parasitic agents. Serpin B2 is upregulated in monocytes from HIV-1 infected patients, and is thought to modulate Th1/Th2 responses. Serpin B2/PAI-2 colocalizes with CHL1 and Vitronectin and mediates neurite outgrowth during post-natal brain development. Inhibition of uPA by SerpinB2 in tumors is associated with a favorable prognosis.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.