SUR1 Antibody Summary
ABCC8 (NP_000343, 611 a.a. – 710 a.a.) partial recombinant protein with GST tag. SEFLSSAEIREEQCAPHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTM
ABCC8 – ATP-binding cassette, sub-family C (CFTR/MRP), member 8
IgG
Polyclonal
Mouse
ABCC8
Unpurified
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Applications/Dilutions
- Western Blot
- ELISA
The quality control of this antibody is limited to WB on the immunizing protein. It has been used for ELISA. Abnovas recommended working dilutions for western analysis are as follows: 1:500 dilution for ascites 1:1000 for purified Ig 1:500
Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Whole antisera with 50% Glycerol
No Preservative
Unpurified
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for SUR1 Antibody
- ABC36
- ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- HHF1Sulfonylurea receptor 1
- HI
- PHHIHRINS
- sulfonylurea receptor (hyperinsulinemia)
- SUR1MRP8
- SURATP-binding cassette transporter sub-family C member 8
- TNDM2ATP-binding cassette sub-family C member 8
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.