SHB Antibody Summary
Peptide with the sequence C-EHLSLLYPVAVRTL from the C terminus of the protein.Sequence according to the Entrez Gene accession number NP_003019
SHB is Src homology (SH2) domaint containing adapter protein with proline rich domains and is likely to be involved in signal transduction of some ligand activated tyrosine kinase receptors.
IgG
Polyclonal
Goat
SHB
IgG purified
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Applications/Dilutions
- Western Blot 1:100-1:2000
Reactivity Notes
Human.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
TBS
0.02% Sodium Azide
0.5 mg/ml
IgG purified
Alternate Names for SHB Antibody
- bA3J10.2
- RP11-3J10.8
- SH2 domain-containing adapter protein B
- SHB (Src homology 2 domain containing) adaptor protein B
- SHB adaptor protein (a Src homology 2 protein)
- SHB
- Src homology 2 domain containing adaptor protein B
Background
SHB is an adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. It may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. It may also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades, and may also regulate IRS1 and IRS2 signaling in insulin-producing cells.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.