Recombinant Human p62/SQSTM1 Protein Summary
A recombinant protein with a C-Terminal His-tag and corresponding to the amino acids 1-356 of Human p62/SQSTM1
Source: E.coli
Amino Acid Sequence: MAMSYVKDDI FRIYIKEKKE CRRDHRPPCA QEAPRNMVHP NVICDGCNGP VVGTRYKCSV CPDYDLCSVC EGKGLHRGHT KLAFPSPFGH LSEGFSHSRW LRKVKHGHFG WPGWEMGPPG NWSPRPPRAG EARPGPTAES ASGPSEDPSV NFLKNVGESV AAALSPLGIE VDIDVEHGGK RSRLTPVSPE SSSTEEKSSS QPSSCCSDPS KPGGNVEGAT QSLAEQMRKI ALESEGRPEE QMESDNCSGG DDDWTHLSSK EVDPSTGELQ SLQMPESEGP SSLDPSQEGP TGLKEAALYP HLPPEADPRL IESLSQMLSM GFSDEGGWLT RLLQTKNYDI GAALDTIQYS KHPPPLLEHH HHHH
E. coli
Recombinant Protein
SQSTM1
>90%, by SDS-PAGE
Applications/Dilutions
39.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT
No Preservative
1 mg/ml
>90%, by SDS-PAGE
Alternate Names for Recombinant Human p62/SQSTM1 Protein
- A170
- EBI3-associated protein of 60 kDa
- EBI3-associated protein p60
- EBIAP
- ORCA
- OSIL
- oxidative stress induced like
- p60PDB3
- p62
- p62B
- Paget disease of bone 3
- PDB3
- phosphotyrosine independent ligand for the Lck SH2 domain p62
- Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
- Sequestosome 1
- sequestosome-1
- SQSTM1
- Ubiquitin-binding protein p62
- ZIP3
Background
p62/SQSTM1 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1 and play a role in titin/TTN downstream signaling in muscle cells. This protein also may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Mutations in the ubiquitin-associated (UBA) domain of the sequestosome 1 protein commonly cause Pagets disease since the UBA is necessary for aggregate sequestration and cell survival. Recombinant p62/SQSTM1 protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.
product targets :　Dopamine Transporter inhibitors