Recombinant Human RAR alpha/NR1B1 Protein Summary
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 68-173 of Human RAR alpha/NR1B1
Source: E.coli
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MSEEIVPSPP SPPPLPRIYK PCFVCQDKSS GYHYGVSACE GCKGFFRRSI QKNMVYTCHR DKNCIINKVT RNRCQYCRLQ KCFEVGMSKE SVRNDRNKKK KEVPKPE
E. coli
Recombinant Protein
RARA
>95% pure by SDS-PAGE
Applications/Dilutions
14 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
20mM Tris pH 7.5, 0.1M NaCl, 5mM beta-mercaptoethanol
No Preservative
1 mg/ml
>95% pure by SDS-PAGE
Alternate Names for Recombinant Human RAR alpha/NR1B1 Protein
- alpha polypeptide
- NR1B1
- RAR alpha
- RARA
- RAR-alpha
- retinoic acid receptor, alpha
Background
Retinoic acid receptors (RAR) belong to the large family of ligand responsive gene regulatory proteins that includes receptors for steroid and thyroid hormones. These proteins contain two highly conserved domains that are involved in determining their DNA and ligand-binding activities. Three isotypes of RARs, alpha, beta, and gamma, are encoded by distinct genetic loci and possess distinct transcriptional properties. Typically, RAR-alpha represses target gene transcription in the absence of hormone, whereas RAR-beta and gamma fail to repress under these conditions. Recombinant human RARalpha, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.
product targets :　Adrenergic Receptor inhibitors