Recombinant Human NKIRAS1 Protein Summary
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-192 of Human NKIRAS1
Source: E.coli
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGKGCKVVVC GLLSVGKTAI LEQLLYGNHT IGMEDCETME DVYMASVETD RGVKEQLHLY DTRGLQEGVE LPKHYFSFAD GFVLVYSVNN LESFQRVELL KKEIDKFKDK KEVAIVVLGN KIDLSEQRQV DAEVAQQWAK SEKVRLWEVT VTDRKTLIEP FTLLASKLSQ PQSKSSFPLP GRKNKGNSNS EN
E. coli
Recombinant Protein
NKIRAS1
>95% pure by SDS-PAGE
Applications/Dilutions
23.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT
No Preservative
0.25 mg/ml
>95% pure by SDS-PAGE
Alternate Names for Recombinant Human NKIRAS1 Protein
- I-kappa-B-interacting Ras-like protein 1
- kappa B-ras 1
- Kappa B-Ras protein 1
- KappaB-Ras1
- KBRAS1kappaB-Ras1
- NF-kappa-B inhibitor-interacting Ras-like protein 1
- NFKB inhibitor interacting Ras-like 1
- NFKB inhibitor interacting Ras-like protein 1
Background
NKIRAS1, also known as NF-kappa-B inhibitor-interacting Ras-like protein 1, belongs to the small GTPase superfamily. NKIRAS1 is atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. It may act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. Recombinant human NKIRAS1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.
product targets :　CRAC Channel inhibitors