Recombinant Human CMP kinase Protein Summary
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-228 of Human CMP kinase
Source: E.coli
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MLSRCRSGLL HVLGLSFLLQ TRRPILLCSP RLMKPLVVFV LGGPGAGKGT QCARIVEKYG YTHLSAGELL RDERKNPDSQ YGELIEKYIK EGKIVPVEIT ISLLKREMDQ TMAANAQKNK FLIDGFPRNQ DNLQGWNKTM DGKADVSFVL FFDCNNEICI ERCLERGKSS GRSDDNRESL EKRIQTYLQS TKPIIDLYEE MGKVKKIDAS KSVDEVFDEV VQIFDKEG
E. coli
Recombinant Protein
CMPK1
>90%, by SDS-PAGE
Applications/Dilutions
28 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 1mM DTT, 100mM NaCl
No Preservative
1 mg/ml
>90%, by SDS-PAGE
Alternate Names for Recombinant Human CMP kinase Protein
- CMKEC 2.7.4.14
- CMPKUMKUMP-CMP kinase
- cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
- Cytidine monophosphate kinase
- Cytidylate kinaseUMP/CMP kinase
- Deoxycytidylate kinase
- EC 2.7.4
- UMP/CMPK
- UMP-CMPK
- UMPKUCK
- Uridine monophosphate kinase
- Uridine monophosphate/cytidine monophosphate kinase
Background
CMPK1, also known as UMP-CMP kinase and deoxycytidylate kinase, is an enzyme that catalyzes the phosphoryl transfer from ATP to UMP, CMP and dCMP. This enzymatic reaction leads to the formation of ADP and the corresponding nucleoside diphosphate, which are required for cellular nucleic acid synthesis. It also plays an important role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. Recombinant human CMPK1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.
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