s12967-016-0816-x

Recombinant Human CCL13/MCP-4 Protein Summary

    Description
    A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 24-98 of Human CCL13/MCP-4

    Source: E.coli

    Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MQPDALNVPS TCCFTFSSKK ISLQRLKSYV ITTSRCPQKA VIFRTKLGKE ICADPKEKWV QNYMKHLGRK AHTLKT

    Source
    E. coli
    Protein/Peptide Type
    Recombinant Protein
    Gene
    CCL13
    Purity
    >90%, by SDS-PAGE
    Endotoxin Note
    < 1.0 EU per 1 microgram of protein (determined by LAL method)

Applications/Dilutions

    Theoretical MW
    10.8 kDa.
    Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

    Storage
    Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
    Buffer
    Phosphate Buffered Saline pH7.4 containing 10% glycerol, 0.1M NaCl, 1mM DTT
    Preservative
    No Preservative
    Concentration
    0.25 mg/ml
    Purity
    >90%, by SDS-PAGE

Alternate Names for Recombinant Human CCL13/MCP-4 Protein

      C-C motif chemokine 13
      CCL13
      chemokine (C-C motif) ligand 13
      CKb10
      MCP4
      MCP-4
      MCP-4Monocyte chemoattractant protein 4
      MGC17134
      NCC-1Monocyte chemotactic protein 4
      NCC1Small-inducible cytokine A13
      new CC chemokine 1
      SCYA13CK-beta-10
      SCYL1
      small inducible cytokine subfamily A (Cys-Cys), member 13

Background

CCL13 is a small cytokine belonging to the CC chemokine family that is also known as thymus and activation regulated chemokine (TARC). This protein induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5. It can be induced by the inflammatory cytokines interleukin-1 and TNF-alpha. Recombinant human CCL13 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

product targets : Pyk9 inhibitors

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