Procalcitonin Antibody (22A11) Summary

ATP2B2plasma membrane calcium ATPase
ATPase, Ca++ transporting, plasma membrane 4
CALC1
CALCA
Calcitonin 1
CGRP
CT
DKFZp686G08106
DKFZp686M088
EC 3.6.3
EC 3.6.3.8
Katacalcin
Matrix-remodeling-associated protein 1
matrix-remodelling associated 1
MXRA1
PCT
Plasma membrane calcium ATPase isoform 4
Plasma membrane calcium pump isoform 4
plasma membrane calcium pump
plasma membrane calcium-transporting ATPase 4
PMCA4b
PMCA4PMCA4x
Preprocalcitonin
Procalcitonin
sarcolemmal calcium pump

Procalcitonin (PCT) is a 116 amino acid residue peptide with molecular weight of about 13 kDa. PCT itself has no known hormonal activity. PCT belongs to a group of related proteins including calcitonin gene-related peptides I and II, amylin, adrenomodulin and calcitonin (CAPA peptide family). PCT, like other peptides of CAPA family, appears from the common precursor pre-procalcitonin consisting of 141 amino acids by removal of 25 amino acids from the N-terminus. PCT undergoes successive cleavages to form three molecules: N-terminal fragment (55 a.a.), calcitonin (32 a.a.) and katacalcin (21 a.a.). Under normal metabolic conditions, PCT is only present in the C cells of the thyroid gland. In bacterial infection and sepsis, however, intact PCT is found in the blood and, more importantly, its level is related to the severity of bacterial sepsis. Today, PCT is considered to be one of the earliest and most specific markers of sepsis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.