PTH Antibody Summary
TCA extracts of human parathyroid glands.
Secreted
This product reacts with humant parathyroid hormone (PTH), a secreted peptide involved in calcium homeostasis.The titre in I125 RIA is <20,000 TT/ml.This antibody has not been cross-adsorbed and may react with homologus peptides from related species.
Polyclonal
Sheep
PTH
IgG purified
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Applications/Dilutions
- ELISA 1:1000-1:2000
- Radioimmunoassay 1:100-1:2000
Reactivity Notes
Human. Not yet tested in other species.
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.09% Sodium Azide
5.0 mg/ml
IgG purified
Alternate Names for PTH Antibody
- Parathormone
- Parathyrin
- parathyroid hormone 1
- parathyroid hormone
- PTH
- PTH1
Background
Parathyroid hormone is secreted by parathyroid cells. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). Most PTH is secreted in its intact, mature 9.5 kDa form, amino acids 1-84; however, it can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. No PTH fragment has been found to be the result of another gene or alternative splicing of the PTH gene.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.