PAR4 Antibody Summary
Synthetic 16 amino acid peptide from C-terminus of human F2RL3 / PAR4.
Integral Memebrane Protein
Human F2RL3 / PAR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Monkey (94%). Backed by our 100% Guarantee.
IgG
Polyclonal
Rabbit
F2RL3
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry-Paraffin 10-25 ug/ml
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (88%), Gibbon (88%), Marmoset (88%).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.1% Sodium Azide
1.0 mg/ml
Immunogen affinity purified
Alternate Names for PAR4 Antibody
- proteinase-activated receptor 4
- coagulation factor II (thrombin) receptor-like 3
- F2RL3
- PAR4
- Protease-Activated Receptor 4
- Thrombin Receptor-like 3
Background
Proteinase-Activated Receptor 4 (PAR4) is a member of the Proteinase-Activated Receptor subfamily. Along with other protease-activated receptors, PAR4 mediates the effects of the enzyme, thrombin which include activation of platelets, leukocytes, endothelial cells, and mesenchymal cells at sites of vascular injury. These cellular responses are triggered through proteolytic activation of the receptors by thrombin. It is believed that PAR3 functions as a cofactor for the cleavage and activation of PAR4. PAR4 expression has been documented in the periphery, primarily in blood platelets.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.