NCAM-1/CD56 Antibody (C5.9) [PE] Summary
Made to Human CD56
Recognises the human CD56 cell surface antigen, NKH-1, expressed by natural killer cells.
IgG2b
Monoclonal
Mouse
NCAM1
IgG purified
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Applications/Dilutions
- Flow Cytometry 1:10-1:1000
Reactivity Notes
Cross reacts with Human.
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS
0.05% Sodium Azide
IgG purified
Alternate Names for NCAM-1/CD56 Antibody (C5.9) [PE]
- CD56 / NCAM-1
- CD56 antigen
- CD56
- MSK39
- NCAM1
- N-CAM-1
- NCAM-1
- NCAMantigen recognized by monoclonal 5.1H11
- neural cell adhesion molecule 1
- neural cell adhesion molecule, NCAM
Background
CD56, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig) like domains. The extracellular part of CD56 consists of five of these Ig domains and two fibronectin type III homology regions. CD56 is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of CD56. Through its extracellular region, CD56 mediates homophilic interactions. In addition, CD56 can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins. CD56 is expressed on most neuroectodermal derived cell lines, tissues and neoplasm such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.