Mer Antibody (108928) [Alexa Fluor® 350] Summary
Glu23-Phe498
Accession # Q60805
Applications/Dilutions
- Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
Notes
Alternate Names for Mer Antibody (108928) [Alexa Fluor® 350]
- c-Eyk
- c-mer proto-oncogene tyrosine kinase
- C-mer
- EC 2.7.10
- EC 2.7.10.1
- MER receptor tyrosine kinase
- Mer
- MerTK
- MGC133349
- Receptor tyrosine kinase MerTK
- RP38Proto-oncogene c-Mer
- STK kinase
- tyrosine-protein kinase Mer
Background
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions (1-2).