Mcl-1 Antibody (22) Summary
Recombinant human Mcl-1 protein
Mcl-1 (22)
IgG1
Monoclonal
Mouse
MCL1
Protein G purified
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Applications/Dilutions
- Western Blot
Reactivity Notes
Human.
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
No buffer
Sodium Azide
Protein G purified
Alternate Names for Mcl-1 Antibody (22)
- BCL2L3
- bcl2-L-3
- BCL2L3MGC104264
- Bcl-2-like protein 3
- Bcl-2-related protein EAT/mcl1
- EAT
- induced myeloid leukemia cell differentiation protein Mcl-1
- Mcl1
- Mcl-1
- mcl1/EAT
- MCL1-ES
- MCL1L
- MCL1S
- MGC1839
- myeloid cell leukemia ES
- myeloid cell leukemia sequence 1 (BCL2-related)
- TM
Background
Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.