MSP R/Ron Antibody Summary
Synthetic 18 amino acid peptide from internal region of human MST1R / RON.
Human MST1R / RON. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FANCE (50%).
Primate (94%), Monkey (100%). Backed by our 100% Guarantee.
IgG
Polyclonal
Rabbit
MST1R
Immunogen affinity purified
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Applications/Dilutions
- ELISA 1:100 – 1:2000
- Immunohistochemistry-Paraffin 3 ug/ml
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gibbon (100%), Marmoste (94%).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.1% Sodium Azide
1.0 mg/ml
Immunogen affinity purified
Alternate Names for MSP R/Ron Antibody
- CD136 antigen
- CD136
- CDw136c-met-related tyrosine kinase
- EC 2.7.10
- EC 2.7.10.1
- macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
- MSP R
- MSP receptor
- MSPR
- MST1R
- p185-Ron
- Protein-tyrosine kinase 8
- PTK8 protein tyrosine kinase 8
- PTK8
- Ron
- RONmacrophage-stimulating protein receptor
- soluble RON variant 1
- soluble RON variant 2
- soluble RON variant 3
- soluble RON variant 4
Background
MST1R/Ron, a HGF Receptor/MET-type protein kinase, mediates the biological activities of macrophage-stimulating protein (MSP), a multifunctional cytokine that regulates cell adhesion, motility, growth, and survival. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uterus.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.