MDR1/ABCB1 Antibody Summary
Synthetic 17 amino acid peptide from cytoplasmic domain of human ABCB1 / MDR1.
cytoplasmic domain of human
Cell Membrane
Human ABCB1 / MDR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Monkey (94%), Primate (100%). Backed by our 100% Guarantee.
IgG
Polyclonal
Rabbit
ABCB1
Immunogen affinity purified
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Applications/Dilutions
- Immunohistochemistry-Paraffin 20 ug/ml
Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Mouse (82%), Hamster (82%).
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.1% Sodium Azide
0.7 mg/ml
Immunogen affinity purified
Alternate Names for MDR1/ABCB1 Antibody
- ABC20
- ABCB1
- ABCB1B
- ATP-binding cassette sub-family B member 1
- ATP-binding cassette, sub-family B (MDR/TAP), member 1
- CD243 antigen
- CD243
- CLCS
- colchicin sensitivity
- doxorubicin resistance
- EC 3.6.3
- EC 3.6.3.44
- GP170
- IBD13
- MDR1
- MDR1MGC163296
- multidrug resistance protein 1
- P-glycoprotein 1
- P-gp
- PGY1
- PGY1P-GP
Background
expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.