MCM7 Antibody (2068B) [Alexa Fluor® 647] Summary
Recombinant Monoclonal Antibody.
E. coli-derived recombinant human MCM7
Gly188-Ala328
Accession # P33993
Gly188-Ala328
Accession # P33993
Detects human MCM7 in direct ELISAs and Western blots.
IgG
Monoclonal
Rabbit
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Applications/Dilutions
- Intracellular Staining by Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
Store the unopened product at 2 – 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for MCM7 Antibody (2068B) [Alexa Fluor® 647]
- CDC47 homolog
- CDC47
- CDC47P85MCM
- DNA replication licensing factor MCM7
- EC 3.6.4.12
- homolog of S. cerevisiae Cdc47
- MCM2
- MCM2PNAS146
- MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
- MCM7
- minichromosome maintenance complex component 7
- minichromosome maintenance deficient (S. cerevisiae) 7
- minichromosome maintenance deficient 7
- P1.1-MCM3
- P1CDC47
- P85MCM
- PNAS146
- PPP1R104
- Protein Phosphatase 1
Background
MCM7/minichromosome maintenance complex component 7, is ahighly conserved mini-chromosome maintenance protein, with ATP binding, DNAhelicase activity and single-stranded DNA binding. MCM7 forms a hexamericprotein complex with MCM2, 4 and 6proteins that has DNA helicase activity essential for the initiation of genereplication. MCM7 also binds to RAD17 tomediate ATR recruitment to damaged DNA. MCM7 expression is repressed inquiescent cells but induced in late G1 to S phase by growth factorstimulation. It is up-regulated in manycancers including colorectal, T cell lymphomas, glioblastoma, and hasprognostic value for hepatocellular carcinoma and gastric adenocarcinoma.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
product targets : Fungal inhibitors