MAD1L1/MAD1 Antibody (9B10) Summary

Cross-reacts with Human. Not yet tested in other species.

hMAD1
HsMAD1
MAD1 mitotic arrest deficient-like 1 (yeast)
MAD1
MAD1L1
MAD1-like protein 1
MAD1yeast, homolog-like 1
Mitotic checkpoint MAD1 protein homolog
PIG9
Tax-binding protein 181
TP53I9
tumor protein p53 inducible protein 9
TXBP181
TXBP181MAD1 (mitotic arrest deficient, yeast, homolog)-like 1

Mitotic checkpoint prevents the transition of eukaryotic cells to anaphase until all the chromosomes have made productive, bipolar attachments through their kinetochores to the microtubules of the mitotic spindle. In Saccharomyces cervisiae six genes are important for the kinetochore-dependent mitotic checkpoint: MAD1, MAD2, MAD3, BUB1, BUB3, and Spindles gene MPS1. All six genes have homologues in higher eukaryotes.1-3 In mammals the mitotic checkpoint is an important mechanism that controls the advance to anaphase during every mitosis. Gene inactivation of MAD2 or Bub3 causes lethality in mice and acquisition of aneuploidy in cell culture. Unattached kinetochores are responsible for generating the checkpoint signal that prevents progression to the anaphase stage. Part of the signal is to inhibit the Cdc20-activated form of a ubiquitin ligase, inhibition of the anaphase promoting complex/cyclosome (APC/C) and inhibition of the ubiquitination of substrates whose destruction is important for the cell to advance to the anaphase stage. Human Mad1 can complex with Mad2 and is preferentially localized to unattached kinetochores during mitosis. Both Mad1 and Mad2 localize to the nuclear pore complex throughout interphase.1-3

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.