Lambda Light Chain Antibody (Mc24-IC6) Summary
Purified human IgG.
Cytoplasmic
Recognises human lambda light chains, and shows no cross- reactivity to kappa light chains or to immunoglobulin heavy chains.
IgG1
Monoclonal
Mouse
IGLC2
Protein A purified
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Applications/Dilutions
- ELISA 1:100-1:2000
- Flow Cytometry 1:10-1:20
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS
0.09% Sodium Azide
0.5 mg/ml
Protein A purified
Alternate Names for Lambda Light Chain Antibody (Mc24-IC6)
- IGLC
- immunoglobulin lambda constant group
Background
All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of Kappa to Lambda is 70:30, the vast majority of which is bound to heavy-chain in immunoglobulin. In normal individuals low levels of free light-chain arepresent in serum (kappa, 1.6-15.2 mg/L; Lambda, 0.4-4.2mg/L), with the occurrence of multiple myeloma or other B-cell malignancies these levels can be greatly elevated and can be found at high levels in the urine (Bence-Jones proteins).
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.