Ki-67/MKI67 Antibody (MM1) Summary
Prokaryotic recombinant protein corresponding to a 1086 bp of Ki-67 motif containing cDNA fragment.
Proliferation Marker
IgG1
Monoclonal
Mouse
MKI67
Tissue culture supernatant
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Applications/Dilutions
- Immunohistochemistry-Paraffin 1:25-1:75
Reactivity Notes
Human
Packaging, Storage & Formulations
Store at 4C. Do not freeze.
No buffer
0.05% Sodium Azide
Tissue culture supernatant
Alternate Names for Ki-67/MKI67 Antibody (MM1)
- antigen identified by monoclonal Ki-67
- antigen KI-67
- Ki67
- Ki-67
- KIA
- Marker Of Proliferation Ki-67
- MIB-1
- MKI67
- PPP1R105
- proliferation-related Ki-67 antigen
- Protein Phosphatase 1
- Regulatory Subunit 105
- TSG126
Background
The antigen defined by mAb Ki-67 is a human nuclear protein, whose expression is strictly associated with cell proliferation. It is widely used in routine pathology as a proliferation marker to measure the growth fraction of cells in human tumors. The protein is present during all active phases of the cell cycle (G (1), S, G (2), and mitosis), but is absent from resting cells (G (0)) and thus is an absolute requirement for progression through the cell-division cycle. The central part of the Ki-67 antigen cDNA contains a large 6,845-bp exon with 16 tandemly repeated 366-bp elements, the Ki-67 repeats, each including a highly conserved new motif of 66 bp, the Ki-67 motif, which encodes for the epitope detected by Ki-67. The gene is localized on 10q25-qter region of human chromosome.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
product targets :　Phenylpropanoids inhibitors